Viral proteases as targets for chemotherapeutic intervention
نویسندگان
چکیده
منابع مشابه
Proteases as drug targets.
The effective management of AIDS with HIV protease inhibitors, or the use of angiotensin-converting enzyme inhibitors to treat hypertension, indicates that proteases do make good drug targets. On the other hand, matrix metalloproteinase (MMP) inhibitors from several companies have failed in both cancer and rheumatoid arthritis clinical trials. Mindful of the MMP inhibitor experience, this chapt...
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Medicinal plants especially leaves are used in traditional medicine for rapid anti-viral therapy against infectious diseases. Protease, a potential candidate in medicinal plants is not so for studied in leaves. So an attempt was made to determine the protease activity of various medicinal plants especially leaves. Buffers of different pH range were used for extraction of the leaves to identify ...
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Viruses of the family Herpesviridae are responsible for a diverse set of human diseases. The available treatments are largely ineffective, with the exception of a few drugs for treatment of herpes simplex virus (HSV) infections. For several members of this DNA virus family, advances have been made recently in the biochemistry and structural biology of the essential viral protease, revealing com...
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Viruses are major pathogenic agents that can cause a variety of serious diseases in humans, other animals, and plants. Due to their clinical and scientific importance, viruses have been under intensive study ever since their first isolation about a century ago. The studies of viruses, their life cycles, and their interactions with the hosts have established many new areas of biological research...
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Galectins are a family of small, highly conserved, molecular effectors that mediate various biological processes, including chemotaxis and angiogenesis, and that function by interacting with various cell surface glycoconjugates, usually targeting β-galactoside epitopes. Because of their significant involvement in various biological functions and pathologies, galectins have become a focus of the...
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ژورنال
عنوان ژورنال: Current Opinion in Biotechnology
سال: 1992
ISSN: 0958-1669
DOI: 10.1016/0958-1669(92)90010-g